Technologies
Newsletters
Please register for our newsletter on the contact us page.
Nanoparticles
For more information about nanoparticles, please visit our sister site Microfluidics UK.
Particle Shape
Particle Shape Analysis
Our range of Occhio instruments provide particle shape analysis starting from 200 nanometers and ranging up to centimetres for laboratory, at-line and on-line solutions.
A particle’s shape, as well as its size, can significantly affect the physical characteristics and process handling of many particulate materials, as well the properties of the product itself, especially for active pharmaceuticals. Studying and understanding the morphology of particles can lead to increases in manufacturing efficiency as well as improvements in product performance.
Image analysis can inspect many thousands of particles to ensure that the results are statistically significant for the sample, even for fibres and touching particles – the type of materials that other methods can find difficult to fully analyse.
Shape analysis is performed by dispersing the particles and viewing them with a high quality light source, optics and camera. Software then analyses the images to determine various properties.
Size and Morphometric Measurements
SIZE
Inner Diameter - (also known as Sieve Diameter) maximum inscribed disc within a particle, computed with a true Euclidean Distance Transform. The fast and accurate algorithm developed is exclusive to Occhio, providing for computing real size distributions.
Area Diameter - diameter of the equivalent area circle.
Mean Diameter - mean of all radii joining the centre of mass and the outline's pixels.
Area and Volume - computed on the particle projected area.
SHAPE
Inertia Elongation - computed from one minus the ratio between inertial ellipse axes.
Feret Bounding Box - bounding box parallel to the Inertia Ellipsoid.
Width and Length - computed directly on this Feret Bounding Box.
Max Distance - maximum distance found within the particle.
Convexity - defined as one minus the ratio between convex area and particle area. The convex area is built with a virtual rubber band fitted on each particle.
Reactivity - (also known as Circularity) defined as the ratio between the equivalent area circle perimeter divided by the actual particle perimeter.
Shape factor - computed with the formula SF=P2/A where P is the Perimeter and A the Area.
For more information contact us.
Particle Shape Research Papers
Review recent papers citing use of Occhio particle shape analysis instruments:
TITLE: Design of Biorelevant Test Setups for the Prediction of Diclofenac In Vivo Features After Oral Administration
AUTHORS: Guhmann, Thommes,Gerber et al - University of Greifswald, Germany
INSTRUMENT: FlowCell FC200S+
USAGE: counting of drug particles was performed applying an optical morphogranulometer based on image analysis technology
View paper
TITLE: Influence of Particle Shape on Size Distribution Measurements by 3D and 2D Image Analysis and Laser Diffraction
AUTHORS: Califice, Michel, Dislaire, Pirard - Univesity of Liege, ArGEnCo, GeMMe, Belgium
INSTRUMENT: Occhio Zephyr
USAGE: obtain the PSD from 2D image analysis
View paper
TITLE: Miniaturized blending and compatibility study with Pimozide and Povidone
AUTHORS: Vriends - Ghent University, Belgium
INSTRUMENT:Occhio Pharma
USAGE: particle size distribution and particle shape are characterized by laser diffraction
View paper
TITLE: Direct Metal Deposition of Functional Graded Structures in Ti- Al System
AUTHORS:Shishkovsky, Missemer, Smurov - Université de Lyon, France
INSTRUMENT: 500 Nano
USAGE: size distribution was studied by means of a granulomorphometer..
View paper
TITLE: Direct Selective Laser Melting of Nitinol Powder
AUTHORS: Shishkovsky, Yadroitsev, Smurov - Université de Lyon, France
INSTRUMENT:500 Nano
USAGE: granulometric analysis of the particles was carried out by an optical granulomorphomete ... a real-time optical sieving system, equipped with the CALLISTO image analysis software
View paper
TITLE: Towards a better control of dairy powder rehydration processes
AUTHORS:Richard, Le Page, Schuck, Andre, Jeantet, Delaplace - INRA-PIHM, France
INSTRUMENT: Occhio
USAGE: Digital images of powder particles were obtained during the course of rehydration, using a granulomorphometer..
View paper
TITLE: Surface Morphology in Selective Laser Melting of Metal Powders
AUTHORS: Yadroitsev, Smurov - Ecole Nationale d’Ingénieurs de Saint-Etienne (ENISE), France
INSTRUMENT:500 Nano
USAGE: geometric dimensions and the shape of surface ... Analysis of the particles was carried out by an optical granulomorphometer
View paper
TITLE: Ultrasound tests in a stirred vessel to evaluate the reconstitution ability of dairy powders
AUTHORS:Richard, Toubal, Le Page, Nassar et al - Institut national de la recherche agronomique, France
INSTRUMENT: FLOWCELL 200SM
USAGE: Using various experimental techniques, it is shown that the shape of the ultrasound ...
View paper
TITLE: Factor analysis of selective laser melting process parameters and geometrical characteristics of synthesized single tracks
AUTHORS: Yadroitsev, Yadroitsava, Bertrand and Smurov - National Engineering School of St-Etienne (ENISE), France
INSTRUMENT:500 Nano
USAGE: Granulomorphological analysis of the particles was carried out by an optical granulomorphometer
View paper
TITLE: Optical analysis of particle size and chromite liberation from pulp samples of a UG2 ore regrinding circuit
AUTHORS: Leroy, Dislaire, Bastin and Pirard - Université de Liège, Belgium
INSTRUMENT:Occhio Callisto software
USAGE: Size and shape analyses
View paper
Tell your network about us...
Tweet Follow @QuantachromeUK